A series of 60 newly synthesized and known quinolone antibacterials, including quinoline-and 1, 8-naphthyridine-3-carboxylic acids, pyrido [2, 3-d] pyrimidine-6-carboxylic acids, and …
Putting human faces on the Church's social teachings: that's what this unique book is about. The author aims to tell the story of Catholic social tradition" from below" and" from above," …
The diverse progenitors that give rise to the human neocortex have been difficult to characterize because progenitors, particularly radial glia (RG), are rare and are defined by a …
Dravet syndrome (DS) is a severe developmental epileptic encephalopathy marked by treatment-resistant seizures, developmental delay, intellectual disability, motor deficits, and a 10 …
Viral genetic tools that target specific brain cell types could transform basic neuroscience and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …
Crossing the blood–brain barrier in primates is a major obstacle for gene delivery to the brain. Adeno-associated viruses (AAVs) promise robust, non-invasive gene delivery from the …
We present an enhancer-AAV toolbox for accessing and perturbing striatal cell types and circuits. Best-in-class vectors were curated for accessing major striatal neuron populations …
Aims Familial hypertrophic cardiomyopathy (HCM) is one the most common heart disorders, with gene mutations in the cardiac sarcomere. Studying HCM with patient-specific induced …
The mammalian cortex is comprised of cells classified into types according to shared properties. Defining the contribution of each cell type to the processes guided by the cortex is …
This paper describes NL-OOPS, a CASE tool that supports requirements analysis by generating object oriented models from natural language requirements documents. The full natural …