Introduction: Protease-activated receptor 2 (PAR-2) is a G protein-coupled receptor that functions as a cell-surface sensor for coagulation factors, as well as other proteases associated …
There is substantial evidence that the mainly tumor-restricted aberrant expression of the highly immunogenic cancer-testis (CT) antigens across several different cancer types makes …
Background: Tipifarnib, a farnesyl transferase inhibitor, was initially designed to prevent Ras farnesylation and its subsequent membrane localization, which is necessary for Ras …
Purpose: As science and technology advance, social civilization progresses, and individuals garner increased attention. Consequently, the focus on mental health has reached new …
Background and Aims: Gallbladder cancer, a relatively rare malignancy, is highly lethal with a 5-year relative survival rate of 15%. Men and women with cholesterol gallstones face …
Introduction: African American men have the highest incidence and death rates from prostate cancer in the United States. The insulinlike growth factor (IGF) axis has been implicated in …
Background: The incidence of prostate cancer (PCa) is approximately 60% higher and the mortality rate 2 to 3 times greater among African American men (AA) in the US compared to …
The interaction between tumor cells and their immunosuppressive microenvironment promotes tumor progression and drug resistance. Thus, simultaneously targeting tumor cells and …
Breast cancer is a poorly understood and under-studied disease in Hispanic/Latina women in the US Breast cancer mortality rates are increasing in Mexico, particularly among younger …
The burden of cancer on the diverse US population is not equal. Enduring disparities in survival persist by social determinants of health (SDOH) including race/ethnicity, nativity, …