Background— The glucagon-like peptide 1 receptor (GLP-1R) is believed to mediate glucoregulatory and cardiovascular effects of the incretin hormone GLP-1(7-36) (GLP-1), which is …
Climate models project that heavy precipitation events intensify with climate change. It is generally accepted that extreme day‐long events will increase at a rate of about 6–7% per …
Human autoimmune (AI) diseases are difficult to treat, because immunosuppressive drugs are nonspecific, produce high levels of adverse effects, and are not based on mechanistic …
We report the observation of a narrow charmoniumlike state produced in the exclusive decay process B ± → K ± π + π - J / ψ . This state, which decays into π + π - J / ψ , has a mass of …
Background The need for repeated treatment of restenosis of a treated vessel remains the main limitation of percutaneous coronary revascularization. Because sirolimus (rapamycin) …
Using the atomic structures of the large ribosomal subunit fromHaloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and …
Interleukin-1 receptors were mapped and characterized in mouse brain by quantitative autoradiography using human recombinant [ 125 I]interleukin-1α and [ 125 I]interleukin-1β as …
To clearly portray the mechanical behavior of the shear process and to relate three-dimensional surface morphology to the shear strength of rock joints, we propose a new method, the …
Central to innate immunity is the sensing of pathogen-associated molecular patterns by cytosolic and membrane-associated receptors 1 , 2 , 3 , 4 . In particular, DNA is a potent activator …
Serendipity is one of the many factors that may contribute to drug discovery. It has played a role in the discovery of prototype psychotropic drugs that led to modern pharmacological …