Engineered T cells, reprogrammed to express chimeric antigen receptors (CAR) or T cell receptors (TCR), have transformed cancer treatment and are being explored as therapeutics for …
G-protein-coupled receptor (GPCR) signalling occurs through heterotrimeric G proteins, whose selective activation leads to distinct cellular outcomes 1 . Although more than 200 GPCR–…
Almost all tumours carry one or more cancer driver mutations, which are essential for cell transformation. However, recent advances in cancer genomics have demonstrated that normal …
The prevalence of metabolic-dysfunction-associated steatohepatitis (MASH) is rising globally, yet effective treatments remain limited 1 . Here we found that systemic or hepatocyte-…
The co-occurrence of germline and somatic oncogenic alterations is frequently observed in breast cancer, yet their combined influence on tumour evolution and therapy resistance …
The impacts of sea-level rise and other hazards on the coasts of the world are determined by coastal sea-level height and land elevation 1 . Correct integration of both aspects is …
The ability of cancer cells to consistently escape therapy highlights their remarkable adaptive potential. A longstanding debate in cancer research concerns whether drug resistance …
Quantum computing represents a central challenge in modern science. Neutral atoms in optical lattices have emerged as a leading computing platform, with collisional gates offering a …
Subtle changes in molecular structure can lead to profound changes in molecular function. However, even minor structural refinements can require the complete resynthesis of a target …
Large language models (LLMs) are increasingly used to generate data to train improved models 1–3, but it remains unclear what properties are transmitted in this model distillation 4, 5. …