Kaguku Kogyo Co., Japan). Hemoglo-bin peaks are detected by bichromatic spectrophotometry and quantified by integration of peak areas. Hemoglobins Aia and Aib are not resolved …
This paper describes the reliability assessment of reinforced concrete columns designed according to the BS 81I0 (1997) ultimate limit state requirements. A typical cross-section (400 …
… Testosterone production was less affected by R 8110 than by etomidate. The increase of … reactions to R 8110. For inhibition of ovarian oestradiol production, R 8110 was twenty times …
Inhibitory receptors like PD-1 and CTLA-4 contribute to T cell dysfunction in cancer 1 , 2 – 3 . Monoclonal antibodies (mAbs) blocking the interactions in trans of these receptors with their …
Paternal care is rare among mammals and the neural mechanisms governing its emergence are poorly understood1. We leveraged the natural paternal behaviour of African striped …
Distinct ligands for the same G-protein-coupled receptor (GPCR) activate intracellular signalling partners to varying extents, but the molecular mechanisms that drive these differences …
Copy number variants (CNVs) are key drivers of human diversity and disease risk 1 . Here we evaluate the role of CNVs across a broad range of human phenotypes and diseases by …
G-protein-coupled receptors (GPCRs) are capable of signalling through four families of G protein α subunits. Although hundreds of nucleotide-free GPCR–G protein complex structures …
G-protein-coupled receptor (GPCR) signalling occurs through heterotrimeric G proteins, whose selective activation leads to distinct cellular outcomes 1 . Although more than 200 GPCR–…
Four patients with myelomatosis (one IgG-x-type, two IgA-x, and one Bence-Jones-x) were given human leucocyte interferon as the only treatment for from 3 to 19 months. Remission …