… Rak, we expressed FLAG-tagged wild-type Rak and Rak mutants lacking an SH2 domain (RakDSH2) or an SH3 domain (Rak-… of Rak, we investigated whether PTEN is a Rak substrate. …
Microparticles (MP) are vesicular structures released from cells upon activation, malignant transformation, stress, or death. MP may be derived from the plasma membrane (shed …
Dominantly acting transforming oncogenes are generally considered to contribute to tumor development and progression by their direct effects on tumor cell proliferation and …
Three-dimensional tumor growth is dependent on the perpetual recruitment of host blood vessels to the tumor site. This recruitment process (mainly via angiogenesis) is thought to be …
Do tej pory koncepcja kulturemów nie była wykorzystywana w pracach, w których badano polski materiał gwarowy1. Dialektolodzy zainteresowani leksyką przede wszystkim gromadzili …
Choroby o podłozu onkologicznym to jedno z najwiekszych wyzwan współczesnej medycyny. Liczba zachorowan rosnie w sposób lawinowy, a złosliwa postac tych schorzen to jedna z …
This chapter reviews the unusual appearance of the robust australopithecine face. Immediately upon the discovery of the robust australopithecines, attention was drawn to their …
Rab proteins are best known for their essential roles in exocytic and endocytic membrane trafficking, which encompass the constitutive and regulated secretory routes, endocytosis via …
Cellular interactions play a crucial role in progression, angiogenesis and invasiveness of tumors, including glioma. The traditionally accepted view is that medium and long-range …
Various conventional chemotherapeutic drugs can block angiogenesis or even kill activated, dividing endothelial cells. Such effects may contribute to the antitumor efficacy of …